- Advance in the treatment of acute heart failure identified
A multicenter study has identified a potential new treatment for acute heart failure, a leading cause of hospitalization and death.
- 1 day ago 26 Apr 24, 1:45am -
- Early trauma cuts life short for squirrels, and climate change could make matters worse
Life can be tough for young red squirrels living in the Canada's Yukon territory, where frigid winters, food scarcity and predators threaten their long-term survival. Scientists want to know what factors might protect young squirrels, especially as their environment becomes more impacted by climate change.
- 1 day ago 26 Apr 24, 1:45am -
- RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease
A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.
- 1 day ago 26 Apr 24, 1:45am -
- Food in sight? The liver is ready!
What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
- 1 day ago 26 Apr 24, 1:45am -
- Treatment for deadly superbug C. diff may be weakening
The antibiotic vancomycin, recommended as first-line treatment for infection caused by the deadly superbug C. difficile (C. diff), may not be living up to its promise, according to new research.
- 1 day ago 25 Apr 24, 10:46pm -
- Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
- 1 day ago 25 Apr 24, 10:45pm -
- AI in medicine: The causality frontier
Machines can learn not only to make predictions, but also to handle causal relationships. An international research team shows how this could make therapies safer, more efficient, and more individualized.
- 1 day ago 25 Apr 24, 10:44pm -
- How electric vehicle drivers can escape range anxiety
Two of the biggest challenges faced by new and potential electric vehicle (EV) drivers are range anxiety and speed of charging, but these shouldn't have to be challenges at all. Researchers discovered that a change in refueling mindset, rather than improving the size or performance of the battery, could be the answer to these concerns.
- 1 day ago 25 Apr 24, 10:44pm -
- Advanced cell atlas opens new doors in biomedical research
Researchers have developed a web-based platform that offers an unprecedented view of the human body at the cellular level. The aim is to create an invaluable resource for researchers worldwide to increase knowledge about human health and disease.
- 1 day ago 25 Apr 24, 10:43pm -
- Using AI to improve diagnosis of rare genetic disorders
Diagnosing rare Mendelian disorders is a labor-intensive task, even for experienced geneticists. Investigators are trying to make the process more efficient using artificial intelligence. The team developed a machine learning system called AI-MARRVEL (AIM) to help prioritize potentially causative variants for Mendelian disorders.
- 1 day ago 25 Apr 24, 10:43pm -
- Maternal grandmothers' support buffers children against the impacts of adversity
A study shows that investment by maternal grandmothers can improve the well-being of grandchildren who have faced adversities in life. The positive effects can last well into adulthood.
- 1 day ago 25 Apr 24, 10:43pm -
- Circadian rhythms can influence drugs' effectiveness
Researchers discovered that more than 300 liver genes are under circadian control: Circadian variations affect how much of a drug is available and how effectively the body can break it down.
- 1 day ago 25 Apr 24, 10:43pm -
- How immune cells communicate to fight viruses
Chemokines are signalling proteins that orchestrate the interaction of immune cells against pathogens and tumors. To understand this complex network, various techniques have been developed to identify chemokine-producing cells. However, it has not yet been possible to determine which cells react to these chemokines. Researchers have now developed a new class of genetically modified mice that enables the simultaneous identification of chemokine producers and sensors.
- 1 day ago 25 Apr 24, 10:43pm -
- National trial safely scaled back prescribing of a powerful antipsychotic for the elderly
Warning letters can safely cut prescribing of a powerful but risky antipsychotic, according to a new study. Researchers used Medicare data to study the effects of the letters on hundreds of thousands of older adults with dementia. They found a significant and lasting reduction in prescribing but no signs of adverse effects on patient health.
- 1 day ago 25 Apr 24, 10:43pm -
- Solving the riddle of the sphingolipids in coronary artery disease
Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.
- 2 days ago 25 Apr 24, 3:55am -